Restraint --------- When awake, ferrets generally exhibit constant activity. They can be easily picked up, however, and gently restrained by using both hands to support their weight and provide security from falling and injury. Ferrets can also be easily restrained for examination, laboratory sample collection and treatment by gently suspending them off their feet by the nape of the neck. The relaxation that results from this method is similar to that exhibited by very young mammals as they are carried in their mother's mouth from one place to another.