Uterine Cancer -------------- The most common tumor of domestic rabbits involves the uterine lining. In breeding rabbits, the early signs of this tumor involve decreased fertility, smaller litter sizes, abortions and stillbirths. In pet rabbits, the most common clinical sign of a uterine tumor is intermittent bleeding from the vulva. This vulvar bleeding is often mistaken for blood in the urine. The volume of hemorrhage can be substantial and alarming. If bleeding is intermittent, the results of a urinalysis may be normal between bleeding episodes. Though this type of tumor can spread to the lungs, spaying of affected does is strongly advised. Because this type of tumor is so common, all pet female rabbits should be spayed after 4 1/2 months of age to avoid difficulties with the reproductive tract later in life.