Pemphigus --------- General Information Pemphigus is a group of severe skin disorders resulting from improper functioning of the animal's immune system. Skin changes generally occur in the underarm areas of the front and back legs, face, mouth, nose, or areas around the anus or genitals. A common site for abnormalities is around body openings. The cause of pemphigus is unknown, but all cases involve autoantibody production, in which the animal's immune system produces antibodies that attack its own body cells. Important Points in Treatment 1. Pemphigus is a serious condition, and many cases are eventually fatal. 2. Treatment involves large doses of anti-inflammatory and/or anti-cancer drugs. Side effects are common, and various blood tests and regular physical examinations are necessary to monitor progress and side effects during treatment. 3. Many animals require lifelong therapy. 4. All the medication must be given as directed. Call the doctor if you cannot carry out any prescribed treatment. 5. Watch your pet closely, and report any unusual activities or signs to the doctor. Notify the Doctor if Any of the Following Occur: * Your pet's skin condition worsens or spreads. * Your pet develops new signs. * Your pet's general health declines.